Direct Synthesis of Deuterium-Labeled O-, S-, N-Vinyl Derivatives from Calcium Carbide
2019; Thieme Medical Publishers (Germany); Volume: 51; Issue: 15 Linguagem: Inglês
10.1055/s-0037-1611518
ISSN1437-210X
AutoresMaria S. Ledovskaya, Vladimir V. Voronin, Konstantin S. Rodygin, Alexandra V. Posvyatenko, Ksenia S. Egorova, Valentine P. Ananikov,
Tópico(s)Chemical Synthesis and Analysis
ResumoA novel methodology for the preparation of trideuterovinyl derivatives of high purity directly from alcohols, thiols, and NH-compounds was developed. Commercially available calcium carbide and D2O acted as a D2-acetylene source, and DMSO-d 6 was used to complete the formation of the D2C=C(D)–X fragment (X = O, S, N). Polymerization of a selected trideuterovinylated compound showed a very promising potential of these substances in the synthesis of labeled polymeric materials. Biological activity of the synthesized trideuterovinyl derivatives was evaluated and the results indicated a significant increase of cytotoxicity upon deuteration.
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