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Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

2019; Elsevier BV; Volume: 87; Issue: 12 Linguagem: Inglês

10.1016/j.biopsych.2019.04.022

1873-2402

Xiangzhen Kong, Premika S.W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul Arnold, Francesca Assogna, Justin T. Baker, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P. Brennan, Jan K. Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Benjamin A. Ely, Jamie D. Feusner, Kate D. Fitzgerald, Jean‐Paul Fouché, Egill A. Friðgeirsson, David C. Glahn, Patricia Gruner, Deniz A. Gürsel, Tobias U. Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Anthony James, Fern Jaspers‐Fayer, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Masaru Kuno, Gerd Kvale, Jun Soo Kwon, Luisa Lázaro, Yanni Liu, Christine Löchner, Paulo Marques, Rachel Marsh, Ignacio Martínez‐Zalacaín, David Mataix‐Cols, Sarah E. Medland, José M. Menchón, Luciano Minuzzi, Pedro Silva Moreira, Àstrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Joseph O’Neill, Jose Ángel Pariente, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y.C. Janardhan Reddy, Oana Georgiana Rus-Oswald, Yuki Sakai, João Ricardo Sato, Lianne Schmaal, H. Blair Simpson, Noam Soreni, Carles Soriano‐Mas, Gianfranco Spalletta, Emily Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, David F. Tolin, Aki Tsuchiyagaito, Daan van Rooij, Guido van Wingen, Ganesan Venkatasubramanian, Zhen Wang, Je‐Yeon Yun, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Clyde Francks, Xiangzhen Kong, Premika S.W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul Arnold, Francesca Assogna, Justin T. Baker, Nerisa Banaj, Núria Bargalló, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Daniel Brandeis, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Geraldo F. Busatto, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Froukje E. de Vries, Stella J. de Wit, Erin W. Dickie, Renate Drechsler, Benjamin A. Ely, Madalena Esteves, Andrea Falini, Yu Fang, Jamie D. Feusner, Martijn Figee, Kate D. Fitzgerald, Martine Fontaine, Jean‐Paul Fouché, Egill A. Friðgeirsson, Patricia Gruner, Deniz A. Gürsel, Geoff Hall, Sayo Hamatani, Gregory L. Hanna, Bjarne Hansen, Tobias U. Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Neda Jahanshad, Anthony James, Fern Jaspers‐Fayer, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Masaru Kuno, Gerd Kvale, Jun Soo Kwon, Luisa Lázaro, Yanni Liu, Christine Löchner, Ricardo Magalhães, Paulo Marques, Rachel Marsh, Ignacio Martínez‐Zalacaín, Yasutaka Masuda, David Mataix‐Cols, Koji Matsumoto, James T. McCracken, José M. Menchón, Eurípedes C. Miguel, Luciano Minuzzi, Pedro Silva Moreira, Àstrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Jin Narumoto, Seiji Nishida, Erika L. Nurmi, Joseph O’Neill, Jose Ángel Pariente, Chris Perriello, John Piacentini, Fabrizio Piras, Fabrizio Piras, Christopher Pittenger, Sara Poletti, Y.C. Janardhan Reddy, Tim Jonas Reeß, Oana Georgiana Rus-Oswald, Yuki Sakai, João Ricardo Sato, Lianne Schmaal, Eiji Shimizu, H. Blair Simpson, Noam Soreni, Carles Soriano‐Mas, Nuno Sousa, Gianfranco Spalletta, Emily Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, Jumpei Takahashi, Jinsong Tang, Anders Lillevik Thorsen, David F. Tolin, Aki Tsuchiyagaito, Daan van Rooij, Guido van Wingen, Ysbrand D. van der Werf, Dick J. Veltman, Daniela Vecchio, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Yoshinari Abe, Jian Xu, Xiufeng Xu, Kei Yamada, Tokiko Yoshida, Je‐Yeon Yun, Mojtaba Zarei, Qing Zhao, Cong Zhou, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Clyde Francks,

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Background Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen’s d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.