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Validation of a Novel Multivariate Method of Defining HIV-Associated Cognitive Impairment

2019; Oxford University Press; Volume: 6; Issue: 6 Linguagem: Inglês

10.1093/ofid/ofz198

2328-8957

Jonathan Underwood, Davide De Francesco, James H. Cole, Matthan W.A. Caan, Rosan A van Zoest, Ben Schmand, David Sharp, Caroline Sabin, Peter Reiss, Alan Winston, Peter Reiss, Ferdinand W.N.M. Wit, J. Schouten, Katherine W. Kooij, Rosan A van Zoest, B C Elsenga, F R Janssen, M. Heidenrijk, W Zikkenheiner, Marc van der Valk, Neeltje A. Kootstra, A M Harskamp-Holwerda, Iris Maurer, M M Mangas Ruiz, A F Girigorie, Julien Villaudy, Esmay Frankin, Alexander Pasternak, Ben Berkhout, T van der Kuyl, Peter Portegies, Ben Schmand, Gert J. Geurtsen, Jacqueline A. ter Stege, M. Klein Twennaar, Charles B.L.M. Majoie, Matthan W.A. Caan, Tanja Su, Kees Weijer, P H L T Bisschop, Andries Kalsbeek, M Wezel, Ingmar Visser, Henricus G. Ruhé, Claudio Franceschi, Paolo Garagnani, Chiara Pirazzini, Miriam Capri, Fabio Dall’Olio, Mariella Chiricolo, Stefano Salvioli, Jan H.J. Hoeijmakers, Joris Pothof, Maria Prins, Marieke Martens, SJ Moll, Jantien van Berkel, M Totté, Sergey Y. Kovalev, Magnus Gisslén, Dietmar Fuchs, Henrik Zetterberg, Alan Winston, Jonathan Underwood, Lauren McDonald, M Stott, Ken Legg, Andrew Lovell, Otto Erlwein, N Doyle, Cherry Kingsley, David Sharp, Robert Leech, James H. Cole, S Zaheri, M M J Hillebregt, Y M C Ruijs, D P Benschop, David M. Burger, M de Graaff-Teulen, Giovanni Guaraldi, Alexander Bürkle, Thilo Sindlinger, María Moreno‐Villanueva, Adrienne Keller, Caroline Sabin, Davide De Francesco, Claude Libert, Sylviane Dewaele, Marta Boffito, Patrick Mallon, Frank A. Post, Caroline Sabin, Memory Sachikonye, Alan Winston, Jane Anderson, David Asboe, Marta Boffito, Lucy Garvey, Patrick Mallon, Frank A. Post, Anton Pozniak, Caroline Sabin, Memory Sachikonye, Jaime H. Vera, Ian Williams, Alan Winston, Frank A. Post, Lucy J. Campbell, Selin Yurdakul, Sara Okumu, Louise Pollard, Ian Williams, Damilola Otiko, Laura L. Phillips, Rosanna Laverick, Martin Fisher, Amanda Clarke, Jaime H. Vera, Andrew Bexley, Celia Richardson, Patrick Mallon, Alan Macken, Bijan Ghavani-Kia, Joanne Maher, M. M. Byrne, Ailbhe Flaherty, Jane Anderson, Sifiso Mguni, Rebecca A. Clark, Rhiannon Nevin-Dolan, Sambasivarao Pelluri, Margaret Johnson, Nnenna Ngwu, Nargis Hemat, Martin Jones, Anne Carroll, Andrew J. O. Whitehouse, Laura Burgess, Daphne Babalis, Alan Winston, Lucy Garvey, Jonathan Underwood, Matthew A. Stott, Linda McDonald, Marta Boffito, David Asboe, Anton Pozniak, Chris Higgs, Elisha Seah, Stephen Fletcher, Michelle Anthonipillai, Ashley Moyes, Katie Deats, Irtiza Syed, Clive Matthews,

HIV-related health complications and treatments

The optimum method of defining cognitive impairment in virally suppressed people living with HIV is unknown. We evaluated the relationships between cognitive impairment, including using a novel multivariate method (NMM), patient- reported outcome measures (PROMs), and neuroimaging markers of brain structure across 3 cohorts.