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Evaluation of Antiandrogenic Effects in Castrated Rats Treated with Cassia tora Extract

2019; Volume: 5; Issue: 2 Linguagem: Inglês

10.21276/ssr-iijls.2019.5.2.8

2581-8732

Samiya Khan, Pratap Chand Mali,

Toxin Mechanisms and Immunotoxins

Background: Practice of artificially altering the rate of growth of human population control has been implemented by limiting the population's birth rate by contraception.The use of Cassia tora plant products for fertility regulation reveals no side effects, therefore to explore the mode of action on androgen of the plant Cassia tora ethanolic extract was administered orally in castrated male wistar rats to develop a cheap, safe, easily administrable, orally effective and reversible fertility regulation for male.Methods: The control animals (Group A) were treated with sterile distilled water.The animals were subjected to no treatment following their castration for 30 days served as castrated controls (Group B).The seed and stem extracts of the plant, Cassia tora was administered orally to castrated rats (Group C) and testosterone propionate was injected either alone (Group D) or in combination with Cassia tora extract (Group E) to castrated rats.Blood parameters, serum clinical investigations and tissue biochemistry, body and organ weights and level of FSH, LH and testosterone were assessed in all groups.Results: After the treatment of Cassia tora in castrated rats hormone assay reveals anti-androgenic effect of the drug. Conclusion:The results revealed that oral administration of Cassia tora affected male fertility by anti-spermatogenic and anti-androgenic action.The decreased weight of accessory sex organs is suggestive of insufficient androgen levels after the extract treatment.Decreased levels of protein, sialic acid and fructose levels support declined production of testosterone level with the Cassia tora extract treatment in rats.