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Zika virus infection among symptomatic patients from two healthcare centers in Sao Paulo State, Brazil: prevalence, clinical characteristics, viral detection in body fluids and serodynamics

2019; UNIVERSIDADE DE SÃO PAULO; Volume: 61; Linguagem: Inglês

10.1590/s1678-9946201961019

ISSN

1678-9946

Autores

Tânia Regina Tozetto‐Mendoza, Vivian Iida Avelino‐Silva, Sílvia Nunes Szente Fonseca, Ingra Morales Claro, Anderson Vicente de Paula, Anna S. Levin, Éster Cerdeira Sabino, Maria Cássia Mendes-Corrêa, Walter Manso Figueiredo, Alvina Clara Félix, Nathalia C. Santiago Souza, Ângela Costa, Marta Inenami, Rosangela M. Gasparetto da Silva, José Eduardo Levi, Camila Malta Romano, Gláucia Paranhos‐Baccalà, Aluísio Augusto Cotrim Segurado, Philippe Mayaud,

Tópico(s)

COVID-19 epidemiological studies

Resumo

Zika virus (ZIKV) clinical presentation and frequency/duration of shedding need further clarification. Symptomatic ZIKV-infected individuals identified in two hospitals in Sao Paulo State, Brazil, were investigated regarding clinical characteristics, shedding in body fluids, and serodynamics. Ninety-four of 235 symptomatic patients (Site A: 58%; Site B: 16%) had Real-Time PCR-confirmed ZIKV infection; fever, headache and gastrointestinal symptoms were less frequent, and rash was more frequent compared to ZIKV-negative patients. Real-Time PCR in serum had worse performance compared to plasma, while urine had the highest sensitivity. Shedding in genital fluids and saliva was rare. IgM positivity was the highest 28 days (24%); IgG positivity increased >14 days (96%) remaining positive in 94% of patients >28 days. ZIKV prevalence varied importantly in two neighboring cities during the same transmission season. Urine Real-Time PCR can improve diagnostic sensitivity; serum testing is less useful. Accurate serological tests are needed to improve diagnosis and surveillance.

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