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High Prevalence of Multidrug Resistant Bacteria in Cirrhotic Patients with Spontaneous Bacterial Peritonitis: Is It Time to Change the Standard Antimicrobial Approach?

2019; Pulsus Group; Volume: 2019; Linguagem: Inglês

10.1155/2019/6963910

2291-2797

Jerônimo de Conto Oliveira, Enrique Carrera, R. Petry, Caroline Deutschendorf, Augusto Mantovani, Samantha Thifani Alrutz Barcelos, Santiago Cassales, Fernando Comunello Schacher, Antônio B. Lopes, Mário Reis Álvares‐da‐Silva,

Hepatitis Viruses Studies and Epidemiology

Introduction. Spontaneous bacterial peritonitis (SBP) has a deleterious clinical impact in end-stage liver disease, and multidrug resistance has increased, raising concern about effectiveness of traditional antibiotic regimens. Patients and Methods . Single-center retrospective study of ascitic fluid infections in cirrhotic patients. Results . We analyzed medical records related to 2129 culture-positive ascitic fluid and found 183 samples from cirrhotic patients. There were 113 monobacterial SBP cases from 97 cirrhotic patients; 57% of patients were male; hepatitis C and alcohol were the main etiologies for cirrhosis. Multidrug resistant bacteria were isolated in 46.9% of SBP samples, and third-generation cephalosporin and quinolone resistant reached 38.9% and 25.7% of SBP cases. Conclusion . SBP due to multidrug resistant bacteria is a growing problem, and one should consider reported resistance profiles for the decision-making process of empirical first-line treatment prescription.