Produção Nacional
Revisado por pares
<p>The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population</p>
2019; Dove Medical Press; Volume: Volume 12; Linguagem: Inglês
10.2147/dmso.s199542
ISSN1178-7007
AutoresAna Carolina Proença da Fonseca, Gabriella de Medeiros Abreu, Verônica Marques Zembrzuski, Mário Campos, João Régis Ivar Carneiro, José Firmino Nogueira Neto, Giselda Maria Kalil de Cabello, Pedro Hernán Cabello,
Tópico(s)Adipose Tissue and Metabolism
ResumoObesity occurs due to the interaction between the genetic background and environmental factors, including an increased food intake and a sedentary lifestyle. Nowadays, it is clear that there is a specific circuit, called leptin-melanocortin pathway, which stimulates and suppresses food intake and energy expenditure. Therefore, the aim of this study was to evaluate the influence of genetic variants related to appetite regulation and energy expenditure on severe obesity susceptibility and metabolic phenotypes in a Brazilian cohort.
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