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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors

2019; Elsevier BV; Volume: 44; Linguagem: Inglês

10.1016/j.ebiom.2019.05.035

ISSN

2352-3964

Autores

Aubrey L. Miller, Samuel C. Fehling, Patrick L. Garcia, Tracy L. Gamblin, Leona N. Council, Robert C.A.M. van Waardenburg, Eddy S. Yang, James E. Bradner, Karina J. Yoon,

Tópico(s)

Cancer-related gene regulation

Resumo

DNA repair deficiency accumulates DNA damage and sensitizes tumor cells to PARP inhibitors (PARPi). Based on our observation that the BET inhibitor JQ1 increases levels of DNA damage, we evaluated the efficacy of JQ1 + the PARPi olaparib in preclinical models of pancreatic ductal adenocarcinoma (PDAC). We also addressed the mechanism by which JQ1 increased DNA damage.

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