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Early Sedation with Dexmedetomidine in Critically Ill Patients

2019; Massachusetts Medical Society; Volume: 380; Issue: 26 Linguagem: Inglês

10.1056/nejmoa1904710

1533-4406

Yahya Shehabi, Belinda Howe, Rinaldo Bellomo, Yaseen M. Arabi, Michael Bailey, Frances Bass, Suhaini Kadiman, Colin McArthur, Lynnette Murray, Michael C. Reade, Ian Seppelt, Jukka Takala, Matt P. Wise, S. A. R. Webb,

Anesthesia and Neurotoxicity Research

Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration of mechanical ventilation and delirium among patients in the intensive care unit (ICU). The use of dexmedetomidine as the sole or primary sedative agent in patients undergoing mechanical ventilation has not been extensively studied.