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Chemical composition and antiproliferative, antioxidant and trypanocidal activities of the fruits from Campomanesia xanthocarpa (Mart.) O. Berg (Myrtaceae)

2019; Taylor & Francis; Volume: 35; Issue: 5 Linguagem: Inglês

10.1080/14786419.2019.1607333

1478-6427

Gustavo Ruivo Salmazzo, Maria Helena Verdan, Flávia Moraes Silva, Regina Maria Barreto Cicarelli, Jonas da Silva Mota, Marcos José Salvador, João Ernesto de Carvalho, Cláudia Andréa Lima Cardoso,

Agricultural and Food Sciences

Chemical investigation of the extracts of the fruits from Campomanesia xanthocarpa resulted in the isolation of six known compounds identified by NMR and comparison with literature data (2′,4′-dihydroxy-5′-methyl-6′-methoxychalcone (1), 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone (2), 2′-hydroxy-3′-methyl-4′,6′-dimethoxychalcone (3), 2′,6′-dihydroxy-3′-methyl-4′-methoxychalcone (4), 5-hydroxy-7-methoxy-8-methylflavanone (5) and 7-hydroxy-5-methoxy-6-methylflavanone (6)). The considerable antioxidant capacity of the extracts was demonstrated by ORAC-FL and DPPH tests. The antiproliferative assay of the extracts and 5 was done in vitro, against many different cancer cell lines besides a healthy one. The extracts presented low cytotoxicity and the substance demonstrated promising results against all the cancer cell lines tested, with IC50 values ranging from 4.75 to 45.81 µmol L−1. The in vitro trypanocidal activity was evaluated against the epimastigote form of the Y strain of Trypanosoma cruzi and an improvement in the activity of the substances 2 (221.81 µmol L−1) and 5 (61.87 µmol L−1) was observed regarding the values obtained for the extracts.