Portal de Periódicos da CAPES

Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study

2019; Elsevier BV; Volume: 256; Linguagem: Inglês

10.1016/j.jad.2019.05.063

1573-2517

Rachel Pascal de Raykeer, Nicolas Hoertel, Carlos Blanco, Pierre Lavaud, Arthur Kaladjian, Yvonne Blumenstock, Christine-Vanessa Cuervo-Lombard, Hugo Peyre, Cédric Lemogne, Frédéric Limosin, J. Adès, Charles Alezrah, I. Amado, Gilles Amar, Oana Cella Andrei, D. Arbault, G. Archambault, G. Aurifeuille, Sarah Barrière, Céline Bera‐Potelle, Yvonne Blumenstock, H. Bardou, M. Bareil-Guérin, P. Barrau, C. Barrouillet, E. Baup, Nadine Bazin, Bruno Beaufils, J. Ben Ayed, Michel Benoît, K. Benyacoub, T. Bichet, F. Blanadet, O. Blanc, J. Blanc-Comiti, Didier Boussiron, Anne-Marie Bouysse, A. Brochard, O. Brochart, B. Bucheron, M. Cabot, Vincent Camus, J.-M. Chabannes, Véronique Charlot, T. Charpeaud, C. Clad-Mor, Céline Combes, M. Comisu, B. Cordier, F. Costi, J. P. Courcelles, M. Creixell, H Cuché, Christine-Vanessa Cuervo-Lombard, A. Dammak, David Da Rin, J. B. Denis, H. Denizot, A. Deperthuis, E. Diers, S. Dirami, D. Donneau, P. Dreano, C. Dubertret, E. Duprat, D. Duthoit, Christine Fernandez, P. Fonfrede, N. Freitas, Philippe Gasnier, J. Gauillard, F. Getten, Fabien Gierski, François Godart, R. Gourevitch, A. Grassin Delyle, J. Gremion, H. Gres, V. Griner, C. Guerin-Langlois, C. Guggiari, O. Guillin, H. Hadaoui, Émmanuel Haffen, Cécile Hanon, S. Haouzir, Cécile Hanon, Anne Héron, Nicolas Hoertel, B. Hubsch, Isabelle Jalenques, Dominique Januel, Arthur Kaladjian, J. F. Karnycheff, Oussama Kébir, Marie‐Odile Krebs, C. Lajugie, Marion Leboyer, P. Legrand, M. Lejoyeux, Vincent Lemaire, E. Leroy, D. Levy-Chavagnat, A. Leydier, C. Liling, Frédéric Limosin, P.M. Llorca, P. Loeffel, P. Louville, Stéphane Lucas, N. Mages, M. Mahi, O. Maillet, Aude Manetti, C. Martelli, P. Martin, M. Masson, I. Maurs-Ferrer, J. Mauvieux, S. Mazmanian, E. Mechin, L. Mekaoui, M. Meniai, A. Metton, A. Mihoubi, María Luisa Limón Mirón, G. Mora, Veronica Ades, P. Nubukpo, C. Omnes, S. Papin, Pierre París, C. Passerieux, J. Pellerin, J. Perlbarg, S. Perron, A. Petit, François Petitjean, Christophe Portefaix, D. Pringuey, A. Radtchenko, H. Rahiou, Delphine Raucher‐Chéné, A. Rauzy, L. Reinheimer, M. Renard, M. René, C.E. Rengade, P. Reynaud, Didier Robin, C. Rodrigues, A. Rollet, Fabien Rondepierre, B. Rousselot, S. Rubingher, G. Saba, Jean-Pierre Salvarelli, Jean‐Claude Samuelian, C. Scemama-Ammar, Franck Schürhoff, Jean‐Pierre Schuster, D. Sechter, B. Segalas, T. Seguret, Anne-Sophie Seigneurie, A. Semmak, F. Slama, S. Taisne, Mohammed Taresh Taleb, J.-L. Terra, D. Thefenne, Eric Tran, R. Tourtauchaux, M.N. Vacheron, Pierre Vandel, V. Vanhoucke, E. Venet, Hélène Verdoux, A. Viala, G. Vidon, M T Vitré, J.L. Vurpas, C. Wagermez, M. Walter, L. Yon, Xavier Zendjidjian,

Family Caregiving in Mental Illness

Little is known about the respective effects of depression and cognitive impairment on quality of life among older adults with schizophrenia spectrum disorder. We used data from the Cohort of individuals with Schizophrenia Aged 55-years or more (CSA) study, a large multicenter sample of older adults with schizophrenia or schizoaffective disorder (N = 353). Quality of life (QoL), depression and cognitive impairment were assessed using the Quality of Life Scale (QLS), the Center of Epidemiologic Studies Depression scale and the Mini-Mental State Examination, respectively. We used structural equation modeling to examine the shared and specific effects of depression and cognitive impairment on QoL, while adjusting for sociodemographic characteristics, general medical conditions, psychotropic medications and the duration of the disorder. Depression and cognitive impairment were positively associated (r = 0.24, p < 0.01) and both independently and negatively impacted on QoL (standardized β = −0.41 and β = −0.32, both p < 0.01) and on each QLS quality-of-life domains, except for depression on instrumental role and cognitive impairment on interpersonal relations in the sensitivity analyses excluding respondents with any missing data. Effects of depression and cognitive impairment on QoL were not due to specific depressive symptoms or specific cognitive domains, but rather mediated through two broad dimensions representing the shared effects across all depressive symptoms and all cognitive deficits, respectively. Because of the cross-sectional design of this study, measures of association do not imply causal associations. Mechanisms underlying these two broad dimensions should be considered as important potential targets to improve quality of life of this vulnerable population.