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Pretransplant Biopsy of Marginal Kidneys: Is It Necessary?

2019; Elsevier BV; Volume: 51; Issue: 5 Linguagem: Inglês

10.1016/j.transproceed.2019.02.023

1873-2623

André Costa Teixeira, Eugénia Ferreira, Maria Guedes Marques, Luís Rodrigues, L. Santos, Catarina Romãozinho, Nuno Afonso, Vítor Sousa, Cristina Targa Ferreira, Fernando Macário, Rui Alves, Arnaldo Figueiredo,

Renal and Vascular Pathologies

Pretransplant kidney biopsy from marginal donors is used to guide the decision of whether to accept or discard organs for transplantation; however, there is controversy about this procedure, and the need for a pretransplant biopsy is still a debate. We sought to determine if histologic evaluation before implantation of marginal kidneys would influence the outcome. Methods. A retrospective observational cohort study of marginal donor transplants at Centro Hospitalar e Universitário de Coimbra was done. From 2009 to 2016, 650 marginal kidney transplants were analyzed. We evaluated long-term graft survival in a cohort of patients who received marginal kidneys. The recipients were divided into 2 groups based on whether a pretransplant donor biopsy was performed. Continuous variables were summarized by mean and standard deviation or median and range, as applicable. Categorical variables were summarized by relative and absolute frequencies. The survival analysis was obtained and plotted using the Kaplan-Meier method and compared with the log-rank test. The median age of recipients and donors were statistically different between both groups (P < .001), with the donors and the recipients being younger in the group without a pretransplant biopsy. The median cold ischemia time was higher in the biopsy group (P = .01). The survival analysis showed that graft survival didn't differ between the groups (P = .2). Selection of kidneys based on histological findings may not influence the graft survival and implies a higher cold ischemia time. More data are necessary to provide insight into which clinical, histologic, and biochemical parameters are necessary for decision making on kidney acceptance.