Anion Receptor Chemistry
2016; Elsevier BV; Volume: 1; Issue: 3 Linguagem: Inglês
10.1016/j.chempr.2016.08.004
ISSN2451-9308
AutoresPhilip A. Gale, Ethan N. W. Howe, Xin Wu,
Tópico(s)Supramolecular Chemistry and Complexes
ResumoThe Bigger pictureAnion receptor chemistry concerns the design of molecules that recognize, respond to, or sense species that carry a negative charge. This area of supramolecular chemistry has a number of applications, including in organocatalysis (where metal-free molecules can catalyze reactions via hydrogen-bonding interactions), in separating mixtures of anions in industrial or radioactive waste, and in producing anion sensors that can be used under real-world conditions to sense trace quantities of anions such as fluoride. Anion receptor chemistry may also be useful in the future treatment of diseases, such as cystic fibrosis, caused by problems with chloride transport through faulty ion channels in epithelial cell membranes. One proposed approach to tackling this is "channel replacement therapy," wherein small molecules facilitate the transport of chloride; significant effort is currently being devoted in this area.SummaryThis review covers advances in anion complexation in 2013, 2014, and 2015. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and fundamental advances in the area.Graphical abstract
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