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CBP/p300 in brain development and plasticity: disentangling the KAT’s cradle

2019; Elsevier BV; Volume: 59; Linguagem: Inglês

10.1016/j.conb.2019.01.023

1873-6882

Michał Lipiński, Beatriz del Blanco, Ángel Barco,

Protein Degradation and Inhibitors

The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues. Both proteins play critical roles during the development of the nervous system and may also regulate stimuli-driven transcription and plasticity in postmitotic neurons. The multiplicity of functions, substrates, and molecular partners, together with the redundancy and singularity of the two KAT3 paralogs, define a complex cat's cradle of relationships. In this review, we discuss the role of the KAT3 proteins in neurons and integrate recent information regarding their function and mode of action.