Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

High prevalence of human T-lymphotropic virus 2 (HTLV-2) infection in villages of the Xikrin tribe (Kayapo), Brazilian Amazon region

2019; BioMed Central; Volume: 19; Issue: 1 Linguagem: Inglês

10.1186/s12879-019-4041-0

ISSN

1471-2334

Autores

Isabel Luís Jocene Braço, Keyla Santos Guedes de Sá, Mishelle Waqasi, Maria Alice Freitas Queiroz, Andrea Nazaré Rangel da Silva, Izaura Maria Vieira Cayres Vallinoto, Sandra Souza Lima, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak, João Farias Guerreiro, Antônio Carlos Rosário Vallinoto,

Tópico(s)

Vector-Borne Animal Diseases

Resumo

Studies have shown that the human T-lymphotropic virus 2 (HTLV-2) is endemic in several indigenous populations of the Brazilian Amazon and molecular analyses have shown the exclusive presence of HTLV-2 subtype 2c among the indigenous groups of this geographical region. The present study characterizes the prevalence of HTLV-2 infection in three new villages of the Xikrin tribe, in the Kayapo group, according to their distribution by sex and age. The study included 263 samples from individuals from the Kateté, Djujeko and Oodjã villages. Plasma samples were tested for the presence of anti-HTLV-1/2 antibodies using enzyme-linked immunosorbent assays (ELISA). Seropositive samples were confirmed using real-time PCR, nested PCR and sequencing. The serological and molecular results confirmed the sole presence of HTLV-2 in 77 (29%) samples, with a prevalence of 38% among women and 18% among men. In these communities, it was found that the prevalence of HTLV-2 infection increased with age. Nucleotide sequences (642 bp, 5'LTR) from eight samples were subjected to phylogenetic analysis by the neighbor-joining method to determine the viral subtype, which confirmed the presence of HTLV-2c. The results of the present study establish the presence of HTLV-2 infection in three new villages of the Xikrin tribe and confirm the high endemicity of the infection in the Kayapo indigenous group of the Brazilian Amazon.

Referência(s)