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BIBTEX RIS

Association between the timing of maternal vaccination and newborns’ anti-pertussis toxin antibody levels

2019; Elsevier BV; Volume: 37; Issue: 36 Linguagem: Inglês

10.1016/j.vaccine.2019.04.079

1873-2518

Lourdes R.A. Vaz-de-Lima, Helena Keico Sato, Eder Gatti Fernandes, Ana Paula Sayuri Sato, Lucia C. Pawloski, M. Lucia Tondella, Cyro Alves de Brito, Expedito José de Albuquerque Luna, Telma Regina Marques Pinto Carvalhanas, Euclides Ayres de Castilho,

Virology and Viral Diseases

Pertussis remains an important global public health concern, despite the presence of extensive immunization programs. Incidence and severity of pertussis are typically higher in neonates and young infants. As a strategy to protect these young infants, maternal vaccination with Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis) has been recommended in Brazil. The objective of this study was to evaluate the effects of Tdap vaccination during pregnancy on the anti-pertussis toxin (PT) IgG response in mothers and their infants at birth. Maternal and cord blood samples were collected from vaccinated (n = 243) and unvaccinated (n = 75) pregnant women, at the time of delivery, from July 2015 to August 2016 in São Paulo, Brazil. Anti-PT IgG antibodies were quantified by Enzyme-Linked Immunosorbent Assay (ELISA) and geometric mean concentrations (GMC) were calculated. Relationship between timing of vaccination and antibody concentrations were evaluated. Maternal and cord blood GMCs among the vaccinated group were 5.4 and 5.6 fold higher [66.5 International Units (IU)/mL and 89.8 IU/mL] compared to the unvaccinated group (12.4 IU/mL and 16.1 IU/mL), respectively (p < 0.001). Higher anti-PT IgG GMCs were observed when vaccination occurred ≥60 days before delivery compared to <60 days, suggesting that vaccination early in the third trimester may be more effective than later in pregnancy. Tdap maternal vaccination results in significantly higher anti-PT IgG in newborn infants and supports the current recommendation of the Brazilian Immunization Program.