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Association of breast and gut microbiota dysbiosis and the risk of breast cancer: a case-control clinical study

2019; BioMed Central; Volume: 19; Issue: 1 Linguagem: Inglês

10.1186/s12885-019-5660-y

1471-2407

Julio Plaza‐Díaz, Ana I. Álvarez‐Mercado, Carmen María Ruiz‐Marín, Iris Reina-Pérez, Alejandro J. Pérez-Alonso, María Belén Sánchez-Andujar, Pablo Torné, Tania Gallart‐Aragón, María Teresa Sánchez‐Barrón, Saturnino Reyes Lartategui, Féderico García, Natalia Chueca, Ana Moreno-Delgado, Katia Torres-Martínez, María José Sáez‐Lara, Cándido Robles-Sánchez, Mariana F. Fernández, Luis Fontana,

Epigenetics and DNA Methylation

Breast cancer ranks first in women, and is the second cause of death in this gender. In addition to genetics, the environment contributes to the development of the disease, although the factors involved are not well known. Among the latter is the influence of microorganisms and, therefore, attention is recently being paid to the mammary microbiota. We hypothesize that the risk of breast cancer could be associated with the composition and functionality of the mammary/gut microbiota, and that exposure to environmental contaminants (endocrine disruptors, EDCs) might contribute to alter these microbiota.