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Drug hypersensitivity in HIV infection

2019; Lippincott Williams & Wilkins; Volume: 19; Issue: 4 Linguagem: Inglês

10.1097/aci.0000000000000545

1528-4050

Jonny Peter, Phuti Choshi, Rannakoe Lehloenya,

HIV/AIDS drug development and treatment

Immune-mediated adverse drug reactions (IM-ADRs) are many times more common in HIV-infected patients. Usual offending drugs include antiretroviral and antiinfectives, but the burden of specific drug IM-ADRs is population-specific; changing as new and fixed dose combinations enter the market, and drug-resistance patterns demand. This review considers recent literature on epidemiology, mechanisms, clinical management and prevention of IM-ADRs amongst persons living with HIV/AIDS.