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Dermal Tattoo Biosensors for Colorimetric Metabolite Detection

2019; Wiley; Volume: 58; Issue: 31 Linguagem: Inglês

10.1002/anie.201904416

1521-3773

Ali K. Yetisen, Rosalia Moreddu, Sarah Seifi, Nan Jiang, Katia Vega, Xingchen Dong, Jie Dong, Haider Butt, Martin Jakobi, Martin Elsner, Alexander W. Koch,

Advanced Sensor and Energy Harvesting Materials

Tattooing is a ubiquitous body modification involving the injection of ink and/or dye pigments into the dermis. Biosensors in the form of tattoos can be used to monitor metabolites in interstitial fluid. Here, minimally invasive, injectable dermal biosensors were developed for measuring pH, glucose, and albumin concentrations. The dermal pH sensor was based on methyl red, bromothymol blue, and phenolphthalein, which responded to a pH range from 5.0 to 9.0. The dermal glucose sensor consisted of glucose oxidase, 3,3',5,5'-tetramethylbenzidine, and peroxidase that detected concentrations up to 50.0 mmol L-1 . The dermal albumin sensor consisted of 3',3'',5',5''-tetrachlorophenol-3,4,5,6-tetrabromosulfophthalein to measure concentrations up to 5.0 g L-1 . The sensors were multiplexed in ex vivo skin tissue and quantitative readouts were obtained using a smartphone camera. These sensors can be used to manage of acid-base homeostasis, diabetes, and liver failure in point-of-care settings.