The Buchwald–Hartwig Amination After 25 Years
2019; Wiley; Volume: 58; Issue: 48 Linguagem: Inglês
10.1002/anie.201904795
ISSN1521-3773
AutoresRuth Dorel, Christian P. Grugel, Alexander M. Haydl,
Tópico(s)Radical Photochemical Reactions
ResumoAbstract The Pd‐catalyzed coupling of aryl (pseudo)halides and amines is one of the most powerful approaches for the formation of C(sp 2 )−N bonds. The pioneering reports from Migita and subsequently Buchwald and Hartwig on the coupling of aminostannanes and aryl bromides rapidly evolved into general and practical tin‐free protocols with broad substrate scope, which led to the establishment of what is now known as the Buchwald–Hartwig amination. This Minireview summarizes the evolution of this cross‐coupling reaction over the course of the past 25 years and illustrates some of the most recent applications of this well‐established methodology.
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