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Guitarrins A–E and Aluminumguitarrin A: 5-Azaindoles from the Northwestern Pacific Marine Sponge Guitarra fimbriata

2019; American Chemical Society; Volume: 82; Issue: 6 Linguagem: Inglês

10.1021/acs.jnatprod.9b00334

1520-6025

Alla G. Guzii, Tatyana N. Makarieva, В. А. Денисенко, А.В. Герасименко, А.А. Удовенко, Roman S. Popov, Pavel S. Dmitrenok, Vasily A. Golotin, Sergey N. Fedorov, Boris B. Grebnev, Valentin A. Stonik,

Marine Biology and Environmental Chemistry

Guitarrins A-E (1-5), the first natural 5-azaindoles, and aluminumguitarrin A (1a), the first aluminum-containing compound from marine invertebrates, were isolated from the sponge Guitarra fimbriata. The structures of these compounds were established using detailed analysis of 1D and 2D NMR data, mass spectra, and X-ray analysis of 1 and 1a. Compound 3 was proved to be a natural inhibitor of alkaline phosphatase.