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Nitro-facilitated ‘5-Exo-dig’ Intramolecular Cyclisation of 2-(2-Nitrophenylethynyl)benzoic Acids: A New Total Synthesis of Indeno[1,2-b]indoles

2002; Thieme Medical Publishers (Germany); Volume: 2002; Issue: 06 Linguagem: Inglês

10.1055/s-2002-31896

1437-2096

Francisco J. Reboredo, Mónica Treus, Juan C. Estévez, Luís Castedo, Ramón J. Estévez,

Synthesis and Biological Evaluation

2-(2′-Nitrophenylethynyl)benzoic acid esters, obtained by Sonagashira coupling of o-bromobenzoates to 2-(2′-nitrophenyl)acetylenes, were converted into indeno[1,2-b]indoles by a two-step sequence, through the corresponding 2-nitrophenyl-1,3-indandiones.