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Synthesis of Iminosugars from Tetroses

2013; Bentham Science Publishers; Volume: 11; Issue: 2 Linguagem: Inglês

10.2174/15701794113106660074

1875-6271

Cristina E. A. Sousa, Raquel R. Mendes, F. Donizete da Costa, Vera C. M. Duarte, A. Gil Fortes, M. José Alves,

Carbohydrate Chemistry and Synthesis

Iminosugars continue receiving a great deal of attention from chemists and biochemists for their potential as pharmaceutics. This is a comprehensive review of the methods found in the literature for the synthesis of piperidine, pyrrolidine, indolizidine, and pirrolizidine iminosugars, starting from D/L-erythrose and D/L-threose carbon chains (tetroses). This review shows the crescent popularity of small molecules to build up iminosugar molecules. Methodologies described herein utilize inexpensive commercial materials. The synthesis of the four tetroses is included referring old and modern methodologies. Keywords: Erythose, indolizidines, piperidines, pyrrolidines, pyrrolizidines, threose.