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N-Glycosides of Amino Acid Amides from Hemerocallis fulva var. sempervirens

2009; Pharmaceutical Society of Japan; Volume: 57; Issue: 10 Linguagem: Inglês

10.1248/cpb.57.1110

1347-5223

Yuko Ogawa, Tenji Konishi,

Agricultural Productivity and Crop Improvement

As part of our search for sedative substances from natural sources, we isolated two novel amino acid amides connected with the fructopyranose, kwansonine A (1) and kwansonine B (2), together with three known amino acid amides, longitubanine A (3), longitubanine B (4), and pinnatanine (5), from Hemerocallis fulva L. var. sempervirens (ARAKI) M. HOTTA. The structures of 1 and 2 have been determined on the spectroscopic evidences as N2-(1-β-D-fructopyranosyl)-N5-(2′,5′-dihydro-2′-furyl-3′-hydroxymethyl)-γ-hydroxyglutamine and N2-(1-β-D-fructopyranosyl)-N5-(2-hydroxymethylbutadienyl)-γ-hydroxyglutamine. This is the first report on the isolation of amino acid amide N-furctoside from Hemerocallis genus plant.