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C8-substituted derivatives of 2-(dipropylamino)tetralin: Palladium-catalyzed synthesis and interactions with 5-HT1A-receptors

1991; Elsevier BV; Volume: 1; Issue: 5 Linguagem: Inglês

10.1016/s0960-894x(01)81038-6

1464-3405

Ye Liu, Björn E. Svensson, Hong Yu, Lourdes Cortizo, Svante B. Ross, Tommy Lewander, Uli Hacksell,

Neuropeptides and Animal Physiology

A series of C8-modified analogues of 8-OH-DPAT (1) have been prepared by facile palladium-catalyzed reactions of the triflates of the enantiomers of 1. Several of the new compounds have high affinity for 5-HT1A-receptors and some are potent agonists.