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Nucleophilic ring closure and opening of aminoiodohydrins

2000; Elsevier BV; Volume: 41; Issue: 8 Linguagem: Inglês

10.1016/s0040-4039(99)02250-9

1873-3581

José M. Concellón, Pablo L. Bernad, Juan A. Perez‐Andres,

Chemical Synthesis and Analysis

Enantiopure aminoiodohydrins obtained from α-aminoaldehydes and Sm/CH2I2 have been transformed into regioisomeric aminoiodohydrins, aminoepoxides, azetidines or 1,3-oxazolidines. The key step in these transformations is a nucleophilic opening–closing process.