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Water is an efficient medium for Wittig reactions employing stabilized ylides and aldehydes

2005; Elsevier BV; Volume: 46; Issue: 26 Linguagem: Inglês

10.1016/j.tetlet.2005.04.105

1873-3581

Jesse Dambacher, Wen‐Xian Zhao, Amer El‐Batta, Robert Anness, Changchun Jiang, Mikael Bergdahl,

Synthesis of β-Lactam Compounds

Water is demonstrated to be an excellent medium for the Wittig reaction employing stabilized ylides and aldehydes. Although the solubility in water appears to be an unimportant characteristic in achieving good chemical yields and E/Z-ratios, the rate of Wittig reactions in water is unexpectedly accelerated.