Cesium propionate as an epoxide cleavage and inversion reagent
2002; Elsevier BV; Volume: 43; Issue: 22 Linguagem: Inglês
10.1016/s0040-4039(02)00739-6
ISSN1873-3581
AutoresDavid O. Arbelo, José Saborit,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoA new epoxide inversion method, based on cesium propionate as the epoxide-cleaving agent, was developed. The initial epoxide-cleavage reaction produced a pair of regioisomeric propionates that were mesylated and methanolyzed to produce the inverted epoxide. Several new epoxides were prepared by this method, including 3,4-epoxy alcohols, which are important precursors for polypropionate synthesis.
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