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Artigo Revisado por pares
BIBTEX RIS

Facile synthesis of enantiopure (−)-TAN1251A

2002; Elsevier BV; Volume: 43; Issue: 13 Linguagem: Inglês

10.1016/s0040-4039(02)00296-4

ISSN

1873-3581

Autores

Hirotake Mizutani, Jun Takayama, Yukio Soeda, Toshio Honda,

Tópico(s)

Synthesis and Catalytic Reactions

Resumo

Formal total synthesis of enantiopure (−)-TAN1251A, a muscarinic M1 receptor antagonist, was achieved via a spirocyclic carbonnitrogen bond formation by the use of aromatic oxidation with bis(acetoxy)iodobenzene as a key step.

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