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Fast and selective oxidation of thioglycosides to glycosyl sulfoxides using KF/m-CPBA

2005; Elsevier BV; Volume: 46; Issue: 47 Linguagem: Inglês

10.1016/j.tetlet.2005.09.132

1873-3581

Geetanjali Agnihotri, Anup Kumar Misra,

Chemical Synthesis and Analysis

A very fast and selective oxidation of thioglycosides to glycosyl sulfoxides has been achieved using KF/m-CPBA in CH3CN–H2O. This protocol has many advantages compared to the currently available methodologies for this transformation in terms of selectivity, yield, reaction time, control of temperature, etc. The yields obtained were excellent in all cases.