Nakadomarin A, a Novel Hexacyclic Manzamine-Related Alkaloid from Amphimedon Sponge
1997; American Chemical Society; Volume: 62; Issue: 26 Linguagem: Inglês
10.1021/jo9715377
ISSN1520-6904
AutoresJun’ichi Kobayashi, Daisuke Watanabe, Naoko Kawasaki, Masashi Tsuda,
Tópico(s)Synthesis and Biological Activity
ResumoA novel manzamine-related alkaloid consisting of unprecedented 8/5/5/5/15/6 ring system, nakadomarin A (1), has been isolated from an Okinawan marine sponge Amphimedon sp., and the unique structure containing a furan ring was elucidated on the basis of the spectroscopic data. The relative stereochemistry was deduced from the NOE data and proton couplings, and a plausible biogenetic path of 1 through ircinal A was proposed.
Referência(s)