Convenient and Versatile Synthesis of Spiro(furan-2,3-indol[2]ones) and Spiro(pyran-2,3-indol[2]ones)
2004; Thieme Medical Publishers (Germany); Issue: 13 Linguagem: Inglês
10.1055/s-2004-832829
ISSN1437-2096
AutoresMario Smet, Chantal Van Oosterwijck, Kristof Van Hecke, Luc Van Meervelt, Annelies Vandendriessche, Wim Dehaen,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoNovel functionalized spiro-3-oxindoles of potential use for the synthesis of natural product analogues and pharmaceutically active compounds were prepared from substituted isatins by a convenient and versatile base-catalyzed condensation and ring-closure reaction. Moreover, a side product consisting of an at present unknown bicyclic skeleton has been isolated.
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