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Microwave-assisted selective and efficient synthesis of 1,3,5-triazinyl mono and bisureas

2014; Elsevier BV; Volume: 70; Issue: 9 Linguagem: Inglês

10.1016/j.tet.2014.01.043

1464-5416

Amparo Ruiz‐Carretero, José Ramón Ramírez, Ana Sánchez‐Migallón, António de la Hoz,

Microwave-Assisted Synthesis and Applications

An efficient and sustainable microwave-assisted approach for the one-step preparation of a wide range of 1,3,5-triazinyl mono- and bisureas has been developed, combining solvent-free conditions and microwave irradiation. In these conditions the very unreactive amino groups of 1,3,5-triazine-2,4-diamines successfully react with phenylisocyanate to yield selectively mono and bisureas. This protocol resulted in the shortest reaction times reported so far and is generally applicable for the preparation of these valuable heterocyclic systems.