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First Total Synthesis of Cassiarin A, a Naturally Occurring Potent Antiplasmodial Alkaloid

2008; American Chemical Society; Volume: 10; Issue: 10 Linguagem: Inglês

10.1021/ol8004112

1523-7060

Marcellino Rudyanto, Yuichiro Tomizawa, Hiroshi Morita, Toshio Honda,

Natural Compounds in Disease Treatment

The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6-endo-dig-cyclization of phenolic oxygens to the resulting alkynes.