A short and facile synthetic route to prenylated flavones. Cyclodehydrogenation of prenylated 2′-hydroxychalcones by a hypervalent iodine reagent
1998; Elsevier BV; Volume: 54; Issue: 45 Linguagem: Inglês
10.1016/s0040-4020(98)00853-9
ISSN1464-5416
AutoresKatalin Gula ́csi, Gyo ̈rgy Litkei, S. Antus, Tama ́s E. Gunda,
Tópico(s)Bioactive natural compounds
ResumoThe first synthesis of the prenylated flavones kanzonol-D (1), -E (3) and yinyanghuo-C (4) was accomplished by cyclodehydrogenation of the appropriately substituted 2′-hydroxychalcones 16, 14 and 11, respectively, in presence of phenyliodine(III) diacetate (PIDA) / potassium hydroxide in methanol. The synthesis of kanzonol-B (13) was also achieved from the 2′-hydroxychalcone 12.
Referência(s)