ASYMMETRIC SYNTHESIS OF 1-ALKYL-2-DEOXYIMINOFURANOSES VIA THE IRIDIUM-CATALYZED INTRAMOLECULAR CYCLIZATION OF AN ALLYLIC CARBONATE
2012; Elsevier BV; Volume: 86; Issue: 2 Linguagem: Inglês
10.3987/com-12-s(n)99
ISSN1881-0942
AutoresHiroki Takahata, Yoshihiro Natori, Shunsuke Kikuchi, Yuichi Yoshimura, Atsushi Kato, Isao Adachi,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoAn asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses was achieved in which the Ir-catalyzed intramolecular cyclization was the key step.The diastereoselective cyclization converted an allylic carbonate into pyrrolidine derivatives.The !-glucosidase inhibitory activities of the prepared 2-deoxyiminofuranoses were also investigated.
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