Catalytic asymmetric one-pot synthesis of α-methylene-γ-lactams
2013; Elsevier BV; Volume: 70; Issue: 1 Linguagem: Inglês
10.1016/j.tet.2013.11.028
ISSN1464-5416
AutoresXavier Companyó, Pierre‐Yves Géant, Andrea Mazzanti, Albert Moyano, Ramón Rios,
Tópico(s)Synthesis and Biological Activity
ResumoAn organocatalytic enantioselective synthesis of α-methylene-γ-lactams has been developed. The reaction between protected 2-aminomalonates and Morita–Baylis–Hillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in excellent yields and moderate to good enantioselectivities, after work-up.
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