Carbon based nucleophilic ring opening of activated monocyclic β-lactams; Synthesis and stereochemical assignment of the ACE inhibitor WF-10129
1995; Elsevier BV; Volume: 51; Issue: 16 Linguagem: Inglês
10.1016/0040-4020(95)00157-4
ISSN1464-5416
AutoresJack E. Baldwin, Robert M. Adlington, Andrew T. Russell, Marie L. Smith,
Tópico(s)Chemical Synthesis and Reactions
ResumoThe preparation of γ-keto α-amino acids via carbon based nucleophilic ring opening of activated monocyclic β-lactams was examined and applied to the synthesis and stereochemical assignment of the dipeptide angiotensin converting enzyme (ACE) inhibitor, WF-10129.
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