Metal catalyzed diazo transfer for the synthesis of azides from amines
1996; Elsevier BV; Volume: 37; Issue: 34 Linguagem: Inglês
10.1016/0040-4039(96)01307-x
ISSN1873-3581
AutoresPhil B. Alper, Shang‐Cheng Hung, Chi‐Huey Wong,
Tópico(s)Chemical Synthesis and Analysis
ResumoAn improved method for the synthesis of azides is described. Diazo transfer from trifly azide effectively with Cu++, Ni++ or Zn++ as a catalyst. The process is amenable to scaleup, can be carried out using commercially available reagents and does not require anhydrous conditions. When metals are scavenged from the reaction, the rate drops by many orders of magnitude.
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