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Mitsunobu reaction modifications allowing product isolation without chromatography: application to a small parallel library

2000; Elsevier BV; Volume: 41; Issue: 6 Linguagem: Inglês

10.1016/s0040-4039(99)02214-5

1873-3581

Jeffrey C. Pelletier, Scott L. Kincaid,

Multicomponent Synthesis of Heterocycles

Readily available reagents, triphenylphosphine resin and di-t-butylazodicarboxylate, were used in Mitsunobu reactions and the byproducts were removed without chromatography. The new modification was utilized to prepare a small, parallel, solution phase library.