Mukaiyama aldol and Michael reactions catalyzed by lanthanide iodides
1998; Elsevier BV; Volume: 54; Issue: 43 Linguagem: Inglês
10.1016/s0040-4020(98)00791-1
ISSN1464-5416
AutoresNicolas Giuseppone, Pierre van de Weghe, Mohamed Mellah, Jacqueline Collin,
Tópico(s)Inorganic and Organometallic Chemistry
ResumoSamarium diiodide is an efficient catalyst precursor which allows the formation of condensation products between various carbonyl compounds and ketene silyl acetals or enoxysilanes. With α,β-unsaturated carbonyl compounds, 1,2- or 1,4-additions are observed according to the structure of the substrate. α,β-Unsaturated ketones yield to enoxysilanes by selective Michael additions. Aldol poducts are isolated as silyl ethers. The mechanisms of the reactions are discussed.
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