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Copper-Catalyzed Double N -Alkenylation of Amides: An Efficient Synthesis of Di- or Trisubstituted N -Acylpyrroles

2007; American Chemical Society; Volume: 72; Issue: 4 Linguagem: Inglês

10.1021/jo062194s

1520-6904

Xiyuan Yuan, Xiaobing Xu, Xiaobo Zhou, Jiwei Yuan, Lugen Mai, Yanzhong Li,

Microbial Natural Products and Biosynthesis

An efficient copper-catalyzed double alkenylation of amides with (1Z,3Z)-1,4-diiodo-1,3-dienes is reported for the first time. The reactions proceed to afford di- or trisubstituted N-acylpyrroles in good to excellent yields using CuI as the catalyst, Cs2CO3 as the base, and rac-trans-N,N'-dimethylcyclohexane-1,2-diamine as the ligand.