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BIBTEX RIS

Copper-Catalyzed Coupling of Tertiary Aliphatic Amines with Terminal Alkynes to Propargylamines via C−H Activation

2008; American Chemical Society; Volume: 73; Issue: 10 Linguagem: Inglês

10.1021/jo800279j

ISSN

1520-6904

Autores

Mingyu Niu, Zhengming Yin, Hua Fu, Yuyang Jiang, Yufen Zhao,

Tópico(s)

Synthesis and Catalytic Reactions

Resumo

We have developed a convenient and efficient method for coupling of tertiary aliphatic amines with terminal alkynes to propargylamines via C−H activation. The protocol uses CuBr as the catalyst, NBS as the free radical initiator, CH3CN as the solvent, and the alkynylation was selectively performed on the methyl of tertiary aliphatic amines at 80 °C. This is an economical and practical method for the synthesis of propargylamines.

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