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Alum Catalyzed Convenient Synthesis of Quino[2,3-b][1,5 benzoxazepine α-Aminophosphonate Derivatives

2009; Wiley; Volume: 30; Issue: 8 Linguagem: Inglês

10.5012/bkcs.2009.30.8.1711

1229-5949

Swapnil S. Sonar, Amol H. Kategaonkar, Nana V. Shitole, Nivrutti R. Jogdand, Bapurao B. Shingate, Murlidhar S. Shingare,

Synthesis of Organic Compounds

We have described an efficient synthesis of quino[2,3-b][1,5]benzoxazepine α-aminophosphonate derivatives by the nucleophilic addition of triethyl phosphite to substituted quino[2,3-b][1,5]benzoxazepines promoted by easily available, inexpensive and mild catalyst KAl(S $O_4)_2{\cdot}12H_2$ O(alum). The reactions proceed smoothly at room temperature under solvent-free reaction conditions and providing high yield of product in very short reaction time.