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Improved Horner-Wadsworth-Emmons Olefination of Base Sensitive γ-Chiral β-Ketophosphonates

1993; Thieme Medical Publishers (Germany); Volume: 1993; Issue: 07 Linguagem: Inglês

10.1055/s-1993-22506

1437-2096

Ari M. P. Koskinen, Ari M. P. Koskinen,

Fluorine in Organic Chemistry

A new modification for the Horner-Wadsworth-Emmons reaction, utilizing K2CO3/MeCN as the base/solvent system, has been developed. The modification is particularly advantageous with base labile chiral phosphonates, exemplified by 1 ???? derived from L-serine.