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Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists

2005; Elsevier BV; Volume: 15; Issue: 17 Linguagem: Inglês

10.1016/j.bmcl.2005.05.054

1464-3405

Alka Bali, Yogita Bansal, Manickam Sugumaran, Jatinder Singh Saggu, Pitchai Balakumar, Gurpreet Kaur, Gulshan Bansal, Ajay Sharma, Manjeet Singh,

Synthesis and biological activity

5-Nitrobenzimidazole derivatives with varying substituents at 2-position have been designed, synthesized, and evaluated for angiotensin II antagonistic activity. A drug-receptor interaction model has been proposed.