Preformed chromatin topology assists transcriptional robustness of Shh during limb development
2019; National Academy of Sciences; Volume: 116; Issue: 25 Linguagem: Inglês
10.1073/pnas.1900672116
ISSN1091-6490
AutoresChristina Paliou, Philine Guckelberger, Robert Schöpflin, Verena Heinrich, Andrea Esposito, Andrea M. Chiariello, Simona Bianco, Carlo Annunziatella, Johannes Helmuth, Stefan A. Haas, Ivana Jerković, Norbert Brieske, Lars Wittler, Bernd Timmermann, Mario Nicodemi, Martin Vingron, Stefan Mundlos, Guillaume Andrey,
Tópico(s)RNA Research and Splicing
ResumoLong-range gene regulation involves physical proximity between enhancers and promoters to generate precise patterns of gene expression in space and time. However, in some cases, proximity coincides with gene activation, whereas, in others, preformed topologies already exist before activation. In this study, we investigate the preformed configuration underlying the regulation of the
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