Synthesis and Antimicrobial Activity of New 4-(Benzylsulfanyl)pyridine Derivatives
1999; Wiley-VCH; Volume: 64; Issue: 2 Linguagem: Inglês
10.1135/cccc19990417
ISSN1212-6950
AutoresVěra Klimešová, Martin Svoboda, Karel Waisser, Milan Pour, Jarmila Kaustová,
Tópico(s)Quinazolinone synthesis and applications
ResumoA series of 4-(benzylsulfanyl)pyridine-2-carbonitriles 2 and 4-(benzylsulfanyl)pyridine-2- carbothioamides 3 was synthesized and their antimycobacterial and antifungal activities were tested. The prepared compounds exhibit significant activity both against M. tuberculosis and nontuberculous mycobacteria. The most active compounds show the MICs of 4 μmol/l. The antifungal activities of 2 are very weak, compounds 3 are inactive against all the tested fungi.
Referência(s)