Novel C 19 Homolignans, Taiwanschirin A, B, and Cytotoxic Taiwanschirin C, and a New C 18 Lignan, Schizanrin A, from Schizandra a risanensis
1999; American Chemical Society; Volume: 64; Issue: 19 Linguagem: Inglês
10.1021/jo990263f
ISSN1520-6904
AutoresYao‐Haur Kuo, Hui‐Chi Huang, Li, Chieh‐Fu Chen,
Tópico(s)Phytochemistry and Biological Activities
ResumoThree novel C19 homolignans with a 3,4-pentano-2,3-dihydrobenzo[b]furan skeleton, taiwanschirin A (1), taiwanschirin B (2), and taiwanschirin C (3), and a new C18 dibenzocyclooctadiene lignan, schizanrin A (4) were isolated from Schizandra arisanensis. Taiwanschirin C (3) and schizarin A (4) exhibited in vitro cytotoxicity against hepatoma (Hepa-3B, ED50 = 2.2 μg/mL for 3, and ED50 = 4.2 μg/mL for 4). Compound 4 also showed marginal activity against colon carcinoma (COLO-205, ED50 = 2.9 μg/mL). Their structural elucidation by spectral and single-crystal X-ray analyses, and structure−activity relationships are discussed.
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