Synthesis of the New Mannosidase Inhibitors, Diversity-Oriented 5-Substituted Swainsonine Analogues, via Stereoselective Mannich Reaction
2004; American Chemical Society; Volume: 6; Issue: 5 Linguagem: Inglês
10.1021/ol049947m
ISSN1523-7060
AutoresTomoya Fujita, Hideko Nagasawa, Yoshihiro Uto, Toshihiro Hashimoto, Yoshinori Asakawa, Hitoshi Hori,
Tópico(s)Bioactive Compounds and Antitumor Agents
Resumo5alpha-substituted swainsonine analogues were synthesized by Mannich reaction of an in situ generated (-)-swainsonine iminium ion intermediate. 5alpha-substituted swainsonine analogues were epimerized to their 5beta-isomers in protic solvent. [reaction: see text]
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